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FUNCTIONAL GENOMICS PANEL

REPORT CONTENT & FEATURES

NUTRIGENOMICS,

VITAMINS & MINERALS REPORT

CATEGORIES COVERED:

Vitamin A
Vitamin B1
Vitamin B2
Vitamin B3
Vitamin B6
Vitamin B7
Vitamin B9

Folate

Vitamin B12
Cobalamin B12
Vitamin C
Vitamin D
Vitamin E
Magnesium
Selenium
Iron Status

NUMBER OF SNPS ANALYSED

GENES INCLUDED:

BCMO1

SLC19A2 SLC19A3

TPK1

SLC52A3 SLC52A2

ETFDH

FMO3

NAMPT

ALPL

BTD

FOLR1

DHFR

SLC19A1

MTHFR

FUT2

TCN1

MTRR

SLC23A1

CYP27B1

CYP2R1

VDR

GSTP1

TRPM6

CNNM2

SEP15

SEPP1

HFE

TMPRSS6

Below is an excerpt from this section, based on a few examples:

CATEGORY	GENE NAME	RSID	RISK GENOTYPE	YOUR GENOTYPE	POSSIBLE OUTCOME	TIPS - EXPRESSION CONTROL	POSSIBLE SYMPTOMS	RECOMMENDED CHECKUP LABS
Vitamin A Metabolism	BCMO1	rs7501331	TT	TT	Your TT genotype means decreased ability to convert Beta-Caroten into the active form of Vitamin A - Retinal. Lower Lutein levels. Single T allele decreases the conversion rate by 32%. References: PMID: 19103647, PMID: 21091228, PMID: 30801647. This SNP has even more impact if combined with T allele on another SNP listed in this report: rs12934922. Click here for more information.	Reduced forms of vitamins B2 and B3, activated in mitochondria, can help the BCMO1 gene function. Iron & Flavonoids promote BCMO1 gene function. Fat intake helps with vit. A absorption. Retinyl palmitate & Retinol can bypass reduced BCMO1 function. Avoid beta-carotene overconsumption. Click here for more information	Dry, itchy eyes. Night blindness. Eye infections. Dry and rough skin patches. Inflamed conjunctiva. Slow growth. Frequent respiratory infections. Impaired immune system. Decreased appetite. Orange skin from carrot juice indicates slow BCMO1. Slow thyroid. Click here to find out more.	Vitamin A Retinol test. Monitor levels over time. Upper daily recommended limit for vitamin A in the retinol form is 10,000 IU per day. Too much vitamin A without enough vitamin D can be a risk factor for osteoporosis.

TT

CATEGORY	GENE NAME	RSID	RISK GENOTYPE	YOUR GENOTYPE	POSSIBLE OUTCOME	TIPS - EXPRESSION CONTROL	POSSIBLE SYMPTOMS	RECOMMENDED CHECKUP LABS
Vitamin B6	ALPL	rs4654748	CC		Your CT genotype means lower vitamin B6 concentrations compared to TT genotype but slightly higher concentration than in CC genotype carriers. References: PMID: 19303062, PMID: 19744961. CC = lower vitamin B6 concentrations compared with CT and TT genotypes.	Some dopamine precursor medication can deplete B6 levels. High homocysteine may increase the need for B6. The following can speed up ALPL expression and therefore may further increase B6 clearance: Caffeic Acid, Curcumin, Resveratrol. P5P is the activated form of B6.	Fatigue. Confusion. Irritability Depression. Anaemia. Nausea. Changes in skin colour. Severe cases: can lead to seizures, an impaired immune system, and kidney stones. Weakened muscles and coordination. Difficulty walking. Numbness and tingling.	Serum Pyridoxal-5-Phosphate (PLP). Homocysteine Test. Urinary 4-Pyridoxic Acid Test, Plasma Pyridoxal Kinase Activity Test.

CT

Copy of Functional Genomics Panel Report

Copy of Copy of Copy of book a practitioner

Comprehensive interpretation features

Possible outcomes: how identified genetic variations in your DNA may contribute to various health effects identified by research.

Possible symptoms to be mindful of, to help verify if any identified genetic variations should be considered a concern.

Helpful lab test suggestions to narrow down markers worth tracking as a long term strategy.

Tips: compounds, substances, supplements, environmental factors and strategies according to their effect on identified genetic risk factors.

LIFESTYLE GENOMICS REPORT

CATEGORIES COVERED:

Alcohol Metabolism & Sensitivity

Allergies > Hay fever

Food Allergies

Food Additives Sensitivity

Caffeine Response

Celiac & Gluten Intolerance

Lactose Tolerance

Fructose Intolerance

Ketogenic Diet

Blood Sugar

Omega fatty acids
Protein digestion
Cholesterol Status
Triglyceride Status
Oxalates
Appetite Control

Mental Hygiene & Stress Response

Environmental exposures / Mould

Environmental exposures / Mercury

Environmental exposures / Lead

Environmental exposures / BPA

Environmental exposures / Pesticides

GENES INCLUDED:

ALDH2
ADH1B
ADH1C
ADH1B
HLA-DQB1
EMSY
IL13
HLA-DRA
RBFOX1
HLA-DQA1
IL18
TMPRSS6
IL4
IL10
IL13
HNMT
ADORA2A
CYP1A2
CYP1A2
HLA-DQ8
HLA DQ 2.2
IL2
IL21
SH2B3
ATXN2
LPP
CCR3
IL18RAP
OLIG3
KIAA1109
MYO9B
IL18R1
MCM6
ALDOB
ACAT1
PPARA
STAT3
APOA5
PLIN1
ADRA2A
PPARGC1A
GIPR
FTO
MYRF
ELOVL2
FADS1
LXR
GSTM3
LIPC
ABCG8
LEPR
PSRC1
USF1
CPT1A
FADS2
MC4R
GALNT2
PEMT
HNF4A
CETP
UCP2
HNF1A
KCTD10
CPT1A
FADS2
APOA5
GALNT2
AGXT
GRHPR
HOGA1
LEPR
TENM4
MC4R
TPH2
GABRA6
GABRG2
ACE
RGS2
BDNF
FKBP5
HTR2A
OXTR
XPC
COMT
ABCC2
CAT
UGT1A
SOD2
CYP2D6
PON1

NUMBER OF SNPS ANALYSED

155

Below is an excerpt from this section, based on a few examples:

CATEGORY	GENE NAME	RSID	RISK GENOTYPE	YOUR GENOTYPE	POSSIBLE OUTCOME	TIPS - EXPRESSION CONTROL	POSSIBLE SYMPTOMS	RECOMMENDED CHECKUP LABS
Food Additives Sensitivity	HNMT	rs1050891	AA		Your AA genotype is associated with Increase in ADHD behaviour in children exposed to certain food additives, due to raised brain histamine levels: sunset yellow, carnosine, tartrazine, ponceau 4R, quinoline yellow, allura red AC, and sodium benzoate.	SAMe is a cofactor for the HNMT gene. L-theanine, Quercetin, Valproic Acid. Probiotics: Bifidobacterium bifidum, Bifidobacterium Infantis, Bifidobacterium longum, Lactobacillus salivarius, Lactobacillus plantarum, Bifidobacterium lactis, Bifidobacterium breve. Avoid exposure to the mentioned food additives.	Some ADHD traits include: Unable to sit still or calm or quiet surroundings, constantly fidgeting, unable to concentrate on tasks, excessive physical movement, excessive talking, unable to wait their turn, acting without thinking, interrupting conversations.	Observation of behaviour. Clinical interview with a child mental health professional. Urinary histamine metabolites ratio: Histamine / N-Methyl Histamine SAM:SAH ratio

AA

CATEGORY	GENE NAME	RSID	RISK GENOTYPE	YOUR GENOTYPE	POSSIBLE OUTCOME	TIPS - EXPRESSION CONTROL	POSSIBLE SYMPTOMS	RECOMMENDED CHECKUP LABS
Ketogenic Diet	PPARA	rs1800206	GG		People with GG genotype may have poor suitability for ketogenic diet but good response to Omega 3 fatty acids.	Reduce saturated fat and increase PUFAs (Poly-Unsaturated Fatty Acids) like Omega 3. Astaxanthin, Resveratrol, Arjunolic acid.	Increased heart disease risk in white people and affecting more men than women	Monitor Triglycerides and cholesterol levels

GG

GASTROINTESTINAL HEALTH

CATEGORY	GENE NAME	RSID	RISK GENOTYPE	YOUR GENOTYPE	POSSIBLE OUTCOME	TIPS - EXPRESSION CONTROL	POSSIBLE SYMPTOMS	RECOMMENDED CHECKUP LABS
Dysbiosis	FUT2	rs601338	AA		A allele = lower levels of Bifidobacterium in the human intestine. PMID: 21625510	Bifidobacterium Probiotics, Prebiotics and resistant starches	Bad breath, upset stomach, nausea, constipation, diarrhoea, difficulty urinating, vaginal or rectal itching, bloating, rash or redness, fatigue, having trouble thinking or concentrating, anxiety, depression and more.	Gut microbiome sequencing

AA

CATEGORIES COVERED:

Esophagitis

GERD

Gastroesophageal reflux disease

Gastritis

H.Pylori

Gut Inflammation /Crohn's Disease

Inflammatory Bowel Disease

IBD

IBS

Ulcerative Colitis

Candida Albicans Overgrowth

Dysbiosis
Norovirus & Gastroenteritis

Intestinal Histamine Intolerance

Intestinal Permeability / Leaky Gut

GENES INCLUDED:

CALM2P1
DSG1
STAT6
GNB3
ABO
IL1B
FUT2
ATG16L1
NOD2
IL23R
ITLN1
TNF
TNFSF15
HNF4A
ZNF365
IL18RAP
TNFRSF1B
TNF -308
STAT4
FCGR2A
IRF5
IFIH1
IL10
LXR
MYO9B
IL17REL
MPO
NOD2
TLR4
AOC1 / DAO
JAK2

NUMBER OF SNPS ANALYSED

Below is an excerpt from this section, based on a few examples:

CATEGORY	GENE NAME	RSID	RISK GENOTYPE	YOUR GENOTYPE	POSSIBLE OUTCOME	TIPS - EXPRESSION CONTROL	POSSIBLE SYMPTOMS	RECOMMENDED CHECKUP LABS
Intestinal Permeability / Leaky Gut	NOD2	rs2066847	II		40% of studied people with II genotype (insertion), who were also healthy relatives of Crohn’s disease patients, had increased intestinal permeability. 75% of those with both: Insertion genotype here and T allele on rs2066844 marker, had increased intestinal permeability. PMID: 16000642	Vitamin D pathway, Butyrate, Resistant Starches and fibre, Omega 3's, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium breve, Bifidobacterium longum, and Saccharomyces boulardii, Curcumin	Chronic diarrhoea, constipation, or bloating, nutritional deficiencies, fatigue, headaches, skin problems, such as acne, rashes, or eczema, joint pain, IBS, IBD, Crohn's, Celiac, food allergies, diabetes, polycystic ovary syndrome, gut-brain axis problems.	Zonulin blood levels, Antigliadin antibodies. Cyrex laboratories performs a good array of tests dealing with intestinal permeability. Monitoring of Th1 associated Interleukins, especially IL12. Monitoring of NfkB levels.

FUNCTIONAL GENOMICS PANEL

REPORT CONTENT & FEATURES

NUTRIGENOMICS,

VITAMINS & MINERALS REPORT

TT

CT

LIFESTYLE GENOMICS REPORT

AA

GG

GASTROINTESTINAL HEALTH

AA

II