DNA & HEALTH REPORTS
REPORT SECTIONS
REPORT SECTIONS
YOUR REPORT IS A PLAN
YOUR REPORT IS A PLAN
DETAILED CATEGORIES
DETAILED CATEGORIES
GENE DESCRIPTIONS
GENE DESCRIPTIONS
SNP DESCRIPTIONS
SNP DESCRIPTIONS


At Lifestyle Genomics Research Centre, we not only recognise, but also respect the immense complexity of human biology and that your genetic SNPs are only part of the riddle behind complex chronic conditions.

We have therefore designed our Variant Report to resemble a strategy plan.

Unlike many reports out there however, this one is not designed simply as a marketing tool, to push easy fixes, or sell subscriptions and supplements.

Although the resources we supply with your report do also list compounds (including dietary supplements) as per their effect on each listed gene, we do not, include lists of recommended supplements as this is a very flawed and potentially dangerous approach.

There are many genetic 'fortune-tellers' out there, but you will discover that these often use marketing gimmicks to either sell supplements or to make DNA data analysis apps or indeed DNA testing services, look appealing, by proposing to offer easy fixes.

Supplements ARE NOT designed to simply target specific genetic SNPs and not do anything else. We recognise that there is in fact a lot of overlap in the action of these compounds. There are many natural substances and supplements that can lower inflammation or help with detoxification, but, at the same time, will have an impact on the levels of your neurotransmitters, and in this way affect your mood as well as cognitive abilities. The same goes for methylation support, mitochondrial support and in general, just about any other body system support.

Then there is the issue of substances that may be right for you but only at the right time, at the right dosage or only to some extent.

Our report reflects our functional approach mindset and therefore the sections of your Variant Report are listed in a particular, strategic order.

Addressing body systems and metabolic functions in the order as listed in your report, may improve the safety and effectiveness of any interventions and help you avoid mistakes.

SECTION I: GI HEALTH (Gastro-Intestinal Health) 




Learn about your genetic susceptibility towards: 


Gluten Intolerance

Crohn'S Disease

Dysbiosis

Gastrointestinal Immunology

H Antigen

Histamine Intolerance

IBD

IBS

IgA

Microbial defence

Microbial defence

Intestinal Permeability

Ulcerative Colitis





GENES ANALYSED HERE*: HLA-DQA1, HLA-DQ8, HLA-DQB1, HLA -DRA, IL2, IL21, ATXN2, LPP, CCR3, IL18RAP, OLIG3, SH2B3, KIAA1109, MYO9B, FUT2, ATG16L1, IL23R, NOD2, TNF -308, HLA-DQA1, ACAT1 G22670A, IL10, IL6, AOC1 / DAO, PON1, TNFRSF1B, FCGR2A, HTR2A, MPO, JAK2, PEMT, IL17REL, CCHCR1




 

SECTION II: IMMUNE FACTORS & INFLAMMATION   



 


Learn about your genetic susceptibility towards: 

Allergies
Autoimmunity
IgA
IgE
IgG
Immune Modulation / Vitamin D & GcMAF
Immune Modulation / Vitamin D Metabolism
Immune Response
Inflammation
Microbial defence
Th17 dominance
Vaccine Response





GENES ANALYSED HERE*: HLA-DQB1, CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-DQB1/ HLA-DQA1, STAT4, TNF -308, PSMB8, HLA-DQA2, CFH, HLA-DPB2, IFIH1, IGF1R, ACKR1, FCER1A, RAD50, SOCS-1, FCGR2A, GSTM3, GC, CYP27B1, CYP2R1, VDR, IL10, IL13 , IL1B, IL4R, IL5, IL6, IL6-174, IL6R, NRG1, STAT1, STAT3, TNF -238, HNF1A-AS1, CRP, ACKR1, FCER1A, CD300LF, HNF1A, HNF4A, NOS2, IL2, IL21 , IRF5, TRAF1, APOE, ATG16L1, GSDMB, LXR, TLR1, TLR3, TNFRSF1B, TLR4, DMRTA1, PON1, TLR2, IL-8, IL-10, MYD88







 SECTION III: CHEMOPROTECTION: DETOX & OXIDATIVE STRESS  





Learn about your genetic susceptibility towards

the functioning of: 


Alcohol Metabolism
Bile Flow
Cell Danger Response
Detox Phase I
Detox Phase II
Detox Phase III
Membranes health
Oxidative Stress
Sulfonation



GENES ANALYSED HERE*: ALDH2, ADH1B,

SULT2A1, VDR, IL10, PXR, GCH1 C36378991T,

GCH1 G55306457C, GSDMB, PPARGC1A ,

CYP1A2*1F, CYP1A2, CYP2C9*6, CYP2C9*3,

CYP2C9*2, CYP2C9*12, CYP2A6*2, CYP1B1,

CYP3A4*1B, CYP2E1, CYP2D6*7, CYP2D6*4,

CYP2C19*3,CYP2C19,NRF2,GSTP1,GSTM3,

GSTM1,ACAT1,UGT1A1, NAT2,

ABCC2, ABCC1 / MRP1, LXR, BHMT, IL6R,

PEMT, G6PD, CAT, GPX1, SOD3, MAOB,

APOE, COX6C, PON1, SOD2, NQO1, IL6,

SULT1A1

 





SECTION IV: MITOCHONDRIAL FUNCTION (ENERGY PRODUCTION) 





GENES ANALYSED HERE*: PPARGC1A , SOD2,

UCP2, ACAT1, COX6C, NDUFS3, NDUFS7















SECTION V: METHYLATION & TRANS-SULFURATION




 
Learn about your genetic susceptibility towards

the functioning of: 



Betaine Metabolism
Cobalamin Cycle
Folate Cycle
Folate Pathway
Homocysteine Metabolism
Methylation Cycle and the MTHFR gene
Methylation / Choline Pathway
Methylation / Creatine Formation
SAMe utilisation
Trans-sulfuration














GENES ANALYSED HERE*: DMGDH, MTRR, DHFR, FOLR, MTHFR, MTHFS, SHMT, SLC19A1, GGH, AHCY, BHMT, CBS, MTR, MAT1A, MTHFD1, PEMT, GAMT, COMT, SUOX, GSS





SECTION VI: NEUROTRANSMITTERS





Learn about your genetic susceptibility towards

the function of: 

Biopterin Cycle
Dopamine & Adrenaline Metabolism
Dopamine Metabolism
Dopamine Synthesis
Glutamate ➜ GABA
Noradrenaline Metabolism
Serotonin & Dopamine Synthesis
Serotonin ➜ Melatonin
Serotonin ➜ Melatonin
Serotonin Receptors













GENES ANALYSED HERE*: PAH, TH, NOS3, DHFR, GCH1, TPH2, COMT, DBH, DRD1, DRD4, DRD2, DRD3, SLC6A3, DAO, MAOA, MAOB, GAD1, GABRA2, GABRA6, NRG1, SLC6A2, ALDH2, CACNA1C, DDC, AANAT, HTR2A






SECTION VII: DIET & NUTRITION





Learn about your genetic susceptibility towards: 


Cholesterol Status
Choline Status
Fat Breakdown
Iron Status
Lactose Tolerance
Monounsaturated Fat
Omega fatty acids
Response to Carbohydrates
Saturated Fat
Selenium Status
Triglyceride Status
Vitamin A metabolism
Vitamin B 12 Status


GENES ANALYSED HERE*: PPARGC1A , ABCG8, LEPR, MYRF, PSRC1, USF1, CPT1A, FADS2 , MC4R, GALNT2, PPARD, FADS1,PEMT, HNF4A, CETP, UCP2, KCTD10, MTR, PNPLA3, MTHFD1, BHMT, APOA5, LIPC, TF, TMPRSS6 , HFE, MCM6, ADIPOQ, FTO, PLIN1, STAT3, CCDC152, CPT1A, FADS2 , APOA5, IGFBP3, BCMO1, FUT2, TCN1






SECTION VIII: GENERAL HEALTH: 


Learn about your genetic susceptibility towards: 


Blood Glucose
Cardiovascular Health
Clotting Factors
Cognitive Function
Diabetes / Obesity
Histamine Metabolism
Hypertension
Joint & Bone Health
Kidney Health
Longevity
Mental Health
Migraines
Mouth Health
Oxalates
Respiratory Health
Skin Health
Sleep quality
Stress Response
Thyroid Health


GENES ANALYSED HERE*:

ACAT1 G22670A, ADIPOQ, ADRA2A, IL10, LXR, PPARGC1A, SOCS3, ABCA1, ADRB2, AGT, APOA1, APOA5, BAG3, CAV1, CDKN2B, GHSR, HFE, HLA-C, HTR2A, IGF1, IL4, KCNN3, LEPR, LOC105377304, MIA3, MIR297, PITX2, NOS3, NPPA, NPPB, PLEKHA7, PSRC1, SH2B3, SOD3, STX18-AS1, VEGFA, ZFHX3, ADD1, CACNA1C, CETP, CYP4V2, F11,F11-AS1, F12, F5, F9, FGB, GP6 Pro219Ser, HRG Pro204Ser, ITGB3, SERPINC1, BDNF, DTNBP1, NRG1, SCN2A, SNAP25, IL6-174, AOC1 / DAO, DAO, MAOB, NAT2, TH, ANO6, ANXA3, C6ORF10, EDIL3, HAPLN1, ERAP1, FCGR2C, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DQB1, IL23R, LOC101928724, LOC105374761, LOC102723649, LOC442263, PTPN22, TRAF1,ACE, HLA-DQA2, MTHFS,ADA, ANK3, C3ORF70, EHHADH-AS1, CYTH1, LOC101928710, LOC105371913, DISC1, FAAH, FURIN, IL1B, SLC6A2 C5884T, SLC6A4, CDKN2B-AS1, DMRTA1, GLT6D1, GRHPR, IL13, LCE3D, LCE3E, NLRP10, OR10A3, UBLCP1, ZNF365, FKBP5, GAD1, OXTR, FOXE1, IL-10










* These genes and SNPs must be included within your raw data, in order to have them included in our report. 



Start with addressing this aspect of your wellbeing if your long term goal is to decrease inflammation, improve immune system function, detoxification, mitochondrial function, methylation and neurotransmitter balance.


Gastro-Intestinal system, although touted by functional medicine as the pillar of health, is not a focus of most genetic reports. 

Addressing your Gastro-Intestinal health may already significantly decrease your inflammation, and also modulate your immune system response.
You can use the results from this section to manage and maintain your inflammatory response, with even more precision.

We recommend that you only progress to directly addressing this aspect of your bio-chemistry, once you have your Gastro -Intestinal health and inflammation under control.

Gut-level inflammation will inhibit the ability of your body to excrete toxic conjugates and thus they can re-enter your bloodstream.

Likewise, systemic inflammation will hinder detoxification pathways wired into your lymphatic system and the extra-cellular matrix. It is not advised to move toxins outside of cells, without the support to your lymphatic system and extra-cellular matrix.

The excretion route is also known as the third phase of your detoxification system (genes for this phase are listed in your report) which involves the lymphatic system, the extra-cellular matrix, bile secretion and transport, gut-level, and kidney-level transport proteins.

This phase is the most neglected and least addressed aspect of detoxification.

Reducing inflammation, modulating immune system function and addressing your chemoprotection and detoxification pathways, will all contribute towards oxidative stress reduction. Increased oxidative stress plays a major role in crippling the ability of your mitochondria to manufacture energy.
It is advised to ensure that there is sufficient support for the integrity of mitochondrial membranes, in order to enable optimal signalling within the complex mitochondrial environment. 

All of the listed above will have an impact on the functioning of your Methylation Pathway.


Folate absorption starts in the gut. Inflammation, pathogens and environmental pollutants clog up the Methylation Pathway and reactions mediated by the key genes involved in the Methylation Cycle, are dependant on mitochondrial performance. 


If you've already optimised your Gastro-Intestinal health, lowered your inflammation, addressed hidden infections and immune system function, optimised all aspects of your detoxification and mitochondrial function, then you have already addressed your Methylation in a very significant way. Now you can start being more specific with the genes and cycles you need to support, going forward.

If you've already optimised your Gastro-Intestinal health, lowered your inflammation, addressed hidden infections and immune system function, optimised all aspects of your detoxification and mitochondrial function, and then worked on the Methylation Pathway then you have already addressed your Neurotransmitters balance in a very significant way. Now you can start being more specific with the genes and cycles you need to support, going forward.
Please note that many substances commonly used to address inflammation, detoxification, mitochondrial function and methylation, may also impact the levels of your neurotransmitters.


Your specific genotypes may influence how you react to these substances, as far as mood and cognitive processing are concerned.

To help you navigate through the maze of the functional approach we have also included sections listed below. This can hopefully aid in bringing into focus and with prioritising some areas over others when it comes to adjusting of dietary and lifestyle choices. 

FUNCTIONAL ACTION PLAN DNA REPORT FEATURING: